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KMID : 0616620040100010197
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Journal of Soonchunhyang Medical College
2004 Volume.10 No. 1 p.197 ~ p.204
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Biocompatibility of continuously bio-ceramic porous body as a biomaterials
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Song Ho-Yeon
Ko Kwang-Kjune
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Abstract
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Continuously Al_(2)O_(3) porous bodies were fabricated by multi-extrusion process. Their biocompatibility was evaluated through in vitro and in-vivo study. Behavior of osteoblast adhesion and proliferation grown on Al_(2)O_(3) porous body was observed. Human osteoblast-like MG-63 cells were grown well on top, bottom, and outside as well as inside surface of porous body. Al_(2)O_(3) the ideal pore size was 150-200 um. The 3- dimensional continuously porous Al_(2)O_(3) body was implanted in subcutaneous tissue of rat for in-vivo study. The porous body was covered with well-developed fibrous tissues and showed the formation of new capillaries in it. No inflammatory response around porous body was found. From the results, the bio-ceramic materials used in the research was proved to have excellent biocompatibility.
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KEYWORD
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Biocompatibility, Al_(2)O_(3) porous body, In-vitro and In-vivo study
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